However, challenge of mice given any of the vaccines led to occurrence of Th2-type immunopathology suggesting hypersensitivity to SARS-CoV components was induced. Caution in proceeding to application of a SARS-CoV vaccine in humans is indicated.”

Tseng, C-T, Sbrana, E., Iwata-Yoshikawa, N., et al. Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus. PLoS ONE, edited by Stefan Poehlmann, vol. 7, no. 4. 20 April 2012. https://doi:10.1371/journal.pone.0035421.