Ivermectin Converts Cold Tumors Hot and Synergizes with Immune Checkpoint Blockade for Treatment of Breast Cancer

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Dobrin Dragaonov et al. We show that treatment with the FDA-approved anti-parasitic drug ivermectin induces immunogenic cancer cell death (ICD) and robust T cell infiltration into breast tumors. As an allosteric modulator of the ATP/P2X4/P2X7 axis which operates in both cancer and immune cells, ivermectin also selectively targets immunosuppressive populations including myeloid cells and Tregs, […]