Protective Effect of Vitamin D Supplementation on COVID-19 Related Intensive Care Hospitalization and Mortality: Definitive Evidence from Meta-Analysis and Trial Sequential Analysis
Christiano Argano et al. The COVID-19 pandemic represents one of the world’s most important challenges for global public healthcare. Various studies have found an association between severe vitamin D deficiency and COVID-19-related outcomes. Vitamin D plays a crucial role in immune function and inflammation. Recent data have suggested a protective role of vitamin D in […]
Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2
Takashi Tanikawa et al. The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged as a pandemic and has inflicted enormous damage on the lives of the people and economy of many countries worldwide. However, therapeutic agents against SARS-CoV-2 remain unclear. SARS-CoV-2 has a spike protein (S protein), and […]
Immunoglobulin Yolk Targeting Spike 1, Receptor Binding Domain of Spike Glycoprotein and Nucleocapsid of SARS-CoV-2 Blocking RBD-ACE2 Binding Reaction
Meliana Eka Saputri et al. Coronavirus disease (COVID)-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become a global pandemic disease that has social and economic chaos. An alternative mitigation strategy may involve the use of specific immunoglobulin (Ig)-Y derived from chicken eggs. Our study aimed to evaluate the neutralizing potential of […]
Chicken Egg Yolk Antibodies (IgYs) Block the Binding of Multiple SARS-C0V-2 Spike Protein Variants to Human ACE2
Shuangshi Wei et al. The SARS-CoV-2 virus is still spreading worldwide, and there is an urgent need to effectively prevent and control this pandemic. This study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against the SARS-CoV-2. We investigated the neutralizing effect of anti-spike-S1 IgYs on the SARS-CoV-2 pseudovirus, as […]
Melatonin as a Potential Treatment for SARS-CoV-2
Joseph Mercola More than 140 scientific studies suggest melatonin is a useful agent for treating SARS- CoV-2, according to research published in Cellular and Molecular Life Sciences. Melatonin was most often researched for its ability to suppress inflammation and the cytokine storm related to COVID-19. When people with COVID-19 were given melatonin, either alone or […]
N-acetyl Cysteine: A Tool to Perturb SARS-CoV-2 Spike Protein Conformation
Utsab Debnath et al. The infection caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) resulted in a pandemic with huge death toll and economic consequences. The virus attaches itself to the human epithelial cells through noncovalent bonding of its spike protein with the angiotensin-converting enzyme-2 (ACE2) receptor on the host cell. We hypothesized that […]
Prevention & Early Treatment for COVID-19
Canadian Covid Care Alliance
Quercetin and Vitamin C: Synergistic Therapy for COVID-19
Joseph Mercola Vitamin C and quercetin have synergistic effects that make them useful in the prevention and early at-home treatment of COVID-19. Both are part of the MATH+ protocol developed by the Front Line COVID-19 Critical Care Working Group (FLCCC). For COVID-19 prophylaxis, the FLCCC recommends vitamin C, quercetin, zinc, melatonin and vitamin D3. The […]
