Polyethylene Gycol as a Cause of Anaphylaxis

Katharina Wylon, Sabine Dölle, Margitta Worm

Polyethylene glycols (PEGs) or macrogols are polyether compounds and are widely used as additives in pharmaceuticals, cosmetics, and food.

Potential life-threatening hypersensitivity reactions to hidden molecules like macrogol may be under- diagnosed. Cases of immediate-type PEG hypersensitivity were reported with increasing frequency. The awareness regarding the allergenic potential of PEG should be raised and a proper product labelling is crucial to prevent PEG mediated hypersensitivity.

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