Pre-exposure to mRNA-LNP Inhibits Adaptive Immune Responses and Alters Innate Immune Fitness in an Inheritable Fashion

Zhen Qin, Aurélie Bouteau, Christoper Herbst, Botond Z. Igyártó

Hundreds of millions of SARS-CoV-2 mRNA-LNP vaccine doses have already been administered to humans. However, we lack a comprehensive understanding of the immune effects of this platform. The mRNA-LNP-based SARS-CoV-2 vaccine is highly inflammatory, and its synthetic ionizable lipid component responsible for the induction of inflammation has a long in vivo half-life. Since chronic inflammation can lead to immune exhaustion and non-responsiveness, we sought to determine the effects of preexposure to the mRNA-LNP on adaptive immune responses and innate immune fitness. We found that pre-exposure to mRNA-LNPs or LNP alone led to long-term inhibition of the adaptive immune responses, which could be overcome using standard adjuvants. On the other hand, we report that after pre-exposure to mRNA-LNPs, the resistance of mice to heterologous infections with influenza virus increased while Candida albicans decreased. The diminished resistance to Candida albicans correlated with a general decrease in blood neutrophil percentages. Interestingly, mice pre-exposed to the mRNA-LNP platform can pass down the acquired immune traits to their offspring, providing better protection against influenza. In summary, the mRNA-LNP vaccine platform induces long-term unexpected immunological changes affecting both adaptive immune responses and heterologous protection against infections. Thus, our studies highlight the need for more research to determine this platform’s true impact on human health.

Latest articles

Bruce Scott In Part I of Menticide 101 and the Brainwashing of...
Bruce Scott It has become quite clear, especially during the last two...
Joseph Mercola Scientists warn repeated COVID boosters may result in lowered immunity...
Mitchell Brent Liester Chlorine dioxide has been condemned as a dangerous poison...
Paul Elkins The recent White House guidance for people to take the...
Igor Chudov The times are changing! Remember how we said that vaccine shedding...

Your donation helps us
stand up for health freedom!

Canada Health Alliance is volunteer run and 100% supported by the generous donations of those who share our concerns and value our work.

Thank you!

The form has been submitted successfully!