Immunoglobulin Yolk Targeting Spike 1, Receptor Binding Domain of Spike Glycoprotein and Nucleocapsid of SARS-CoV-2 Blocking RBD-ACE2 Binding Reaction

Meliana Eka Saputri et al. Coronavirus disease (COVID)-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become a global pandemic disease that has social and economic chaos. An alternative mitigation strategy may involve the use of specific immunoglobulin (Ig)-Y derived from chicken eggs. Our study aimed to evaluate the neutralizing potential of […]

N-acetyl Cysteine: A Tool to Perturb SARS-CoV-2 Spike Protein Conformation

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Utsab Debnath et al. The infection caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) resulted in a pandemic with huge death toll and economic consequences. The virus attaches itself to the human epithelial cells through noncovalent bonding of its spike protein with the angiotensin-converting enzyme-2 (ACE2) receptor on the host cell. We hypothesized that […]

COVID-19, the Gut Microbiota and Glyphosate: What are the Links?

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Michelle Perro UK scientists (Prof. Glenn Gibson, Dr. Gemma Walton, Dr. Kirsty Hunter and Prof. Tim Spector) requested that Matt Hancock (the country’s health secretary) call attention to the links between gut health and SARS-CoV-2 (COVID-19). (The original content of the letter was not located) Via the lung-gut pathway, research suggests a relationship between immunity […]

SARS-CoV-2 Vaccines: Lights and Shadows

Fabio Angeli et al. … Different vaccine platforms are currently available which include live attenuated vaccines, inactivated vaccines, recombinant protein vaccines, vector vaccines, DNA vaccines and RNA vaccines. Vaccines increase the endogenous synthesis of SARS-CoV-2 Spike proteins from a variety of cells. Once synthetized, the Spike proteins assembled in the cytoplasma migrate to the cell […]