Ivermectin Converts Cold Tumors Hot and Synergizes with Immune Checkpoint Blockade for Treatment of Breast Cancer
Dobrin Dragaonov et al. We show that treatment with the FDA-approved anti-parasitic drug ivermectin induces immunogenic cancer cell death (ICD) and robust T cell infiltration into breast tumors. As an allosteric modulator of the ATP/P2X4/P2X7 axis which operates in both cancer and immune cells, ivermectin also selectively targets immunosuppressive populations including myeloid cells and Tregs, […]
Ivermectin Converts Cold Tumors Hot and Synergizes with Immune Checkpoint Blockade for Treatment of Breast Cancer
Dobrin Draganov et al. Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer We show that treatment with the FDA-approved anti-parasitic drug ivermectin induces immunogenic cancer cell death (ICD) and robust T cell infiltration into breast tumors. As an allosteric modulator of the ATP/P2X4/P2X7 axis which operates in […]
