From Explosives to the Gas That Heals: Nitric Oxide in Biology and Medicine

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William Wells et al. Outside the body, NO is an unstable, potentially toxic gas that forms in lightning strikes and car exhaust. But as a messenger molecule inside the body it plays a crucial regulatory role. Every cell type and tissue sends and receives messages—telling muscle cells when to contract, for instance, or fat cells […]

Antiviral Activities of Compounds Isolated from Pinus densiflora (Pine Tree) against the Influenza A Virus

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Thi Kim Quy Ha et al. Pinus densiflora was screened in an ongoing project to discover anti-influenza candidates from natural products. An extensive phytochemical investigation provided 26 compounds, including two new megastigmane glycosides (1 and 2), 21 diterpenoids (3–23), and three flavonoids (24–26). The chemical structures were elucidated by a series of chemical reactions, including […]

High-Dose Inhaled Nitric Oxide for the Treatment of Spontaneously Breathing Pregnant Patients With Severe Coronavirus Disease 2019 (COVID-19) Pneumonia

Carlo Valsecchi et al. Pneumonia related to coronavirus disease 2019 (COVID-19) is particularly threatening during pregnancy, because it may quickly progress to hypoxic respiratory failure requiring hospitalization and cardiopulmonary support … Moreover, the risk of obstetric complications, including preeclampsia, preterm delivery, and stillbirth, is also increased with COVID-19. To date, no respiratory therapies to complement […]