Effect of LNPs on RBCs to Render Them Dysfunctional – Is Obvious
Jessica Rose The LNPs used in the Pfizer and Moderna formulations are a composite of four different lipids (fats): cationic lipids, polyethylene glycol, phospholipids and cholesterol. The latter two are for structural integrity, PEG is for optimizing distribution and stealth qualities in vivo, and the cationic lipids (+) are to hold the mRNA (-) ‘in […]
PEG Supposedly A Harmless Ingredient
Lucy Crisetig Polyethylene Glycol, also goes by the names of PEG, Macrogol, Carbowax and many other names when combined with other substances. During trials, pharmaceutical companies knew anaphylaxis could be a problem, yet it wasn’t until after implementation of the vaccination programs when reports of anaphylactic incidents began to emerge. … PEGs are also used […]
The Pediatric Perils of PEG: From MiraLAX to COVID Shots, FDA and CDC Ignore Safety Signals
Children’s Health Defense Team Last year, the U.S. Food and Drug Administration warned that some ultrasound contrast agents contain polyethylene glycol (PEG) and therefore shouldn’t be administered to patients with known or suspected allergies to PEG — but there are no similar warnings for adults or children who get PEG-containing COVID-19 shots or MiraLAX, an […]
Skin Testing with Pfizer SARS-Cov-2 Vaccine and PEG 2000
João Vieira et al. The Pfizer-BioNTech SARS-CoV-2 vaccine is an mRNA vaccine that uses a lipid-based nanoparticle carrier system, stabilized by polyethylene glycol (PEG) 2000. Although evidence on the pathogenesis of severe immediate reactions to the SARS-CoV-2 vaccine is lacking, the PEG molecule has been proposed as a possible culprit for these reactions due to […]
Anaphylactic Reactions to mRNA COVID-19 Vaccines: A Call for Further Study
Sophia Hatziantoniou et al. The modified mRNA molecule is encased in LNPs, consisting of ionizable, auxiliary and pegylated lipids, as well as cholesterol, which is thought to contribute to the fluidity of the nanoparticle, thus increasing its ability to fuse with the plasma membranes of host cells to deliver the mRNA cargo. … After implementation […]
mRNA Vaccines to Prevent COVID-19 Disease and Reported Allergic Reactions: Current Evidence and Suggested Approach
Aleena Banerji et al. The U.S. Food and Drug Administration (FDA) has recently issued an Emergency Use Authorization (EUA) for 2 highly effective coronavirus disease 2019 (COVID-19) vaccines from Pfizer-BioNTech and Moderna. This has brought hope to millions of Americans in the midst of an ongoing global pandemic. The FDA EUA guidance for both vaccines […]
Polyethylene Gycol as a Cause of Anaphylaxis
Katharina Wylon, Sabine Dölle, Margitta Worm Polyethylene glycols (PEGs) or macrogols are polyether compounds and are widely used as additives in pharmaceuticals, cosmetics, and food. Potential life-threatening hypersensitivity reactions to hidden molecules like macrogol may be under- diagnosed. Cases of immediate-type PEG hypersensitivity were reported with increasing frequency. The awareness regarding the allergenic potential of […]
Polyethylene Glycol (PEG) is a Cause of Anaphylaxis to the Pfizer/BioNTech mRNA COVID-19 Vaccine
Priya Sellaturay et al. Allergy to PEG is rare,5,6 but reactions can be severe or even fatal.7 PEG is an excipient of many drugs, but hypersensitivity de- pends on its molecular weight (MW). … Although the Pfizer/BioNTech vaccine contains a number of excipients, PEG 2000 is the only one reported to cause anaphylaxis. All mRNA […]
