Effect of LNPs on RBCs to Render Them Dysfunctional – Is Obvious

Jessica Rose The LNPs used in the Pfizer and Moderna formulations are a composite of four different lipids (fats): cationic lipids, polyethylene glycol, phospholipids and cholesterol. The latter two are for structural integrity, PEG is for optimizing distribution and stealth qualities in vivo, and the cationic lipids (+) are to hold the mRNA (-) ‘in […]

PEG Supposedly A Harmless Ingredient

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Lucy Crisetig Polyethylene Glycol, also goes by the names of PEG, Macrogol, Carbowax and many other names when combined with other substances. During trials, pharmaceutical companies knew anaphylaxis could be a problem, yet it wasn’t until after implementation of the vaccination programs when reports of anaphylactic incidents began to emerge. … PEGs are also used […]

The Pediatric Perils of PEG: From MiraLAX to COVID Shots, FDA and CDC Ignore Safety Signals

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Children’s Health Defense Team Last year, the U.S. Food and Drug Administration warned that some ultrasound contrast agents contain polyethylene glycol (PEG) and therefore shouldn’t be administered to patients with known or suspected allergies to PEG — but there are no similar warnings for adults or children who get PEG-containing COVID-19 shots or MiraLAX, an […]

Skin Testing with Pfizer SARS-Cov-2 Vaccine and PEG 2000

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João Vieira et al. The Pfizer-BioNTech SARS-CoV-2 vaccine is an mRNA vaccine that uses a lipid-based nanoparticle carrier system, stabilized by polyethylene glycol (PEG) 2000. Although evidence on the pathogenesis of severe immediate reactions to the SARS-CoV-2 vaccine is lacking, the PEG molecule has been proposed as a possible culprit for these reactions due to […]

Anaphylactic Reactions to mRNA COVID-19 Vaccines: A Call for Further Study

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Sophia Hatziantoniou et al. The modified mRNA molecule is encased in LNPs, consisting of ionizable, auxiliary and pegylated lipids, as well as cholesterol, which is thought to contribute to the fluidity of the nanoparticle, thus increasing its ability to fuse with the plasma membranes of host cells to deliver the mRNA cargo. … After implementation […]

Polyethylene Gycol as a Cause of Anaphylaxis

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Katharina Wylon, Sabine Dölle, Margitta Worm Polyethylene glycols (PEGs) or macrogols are polyether compounds and are widely used as additives in pharmaceuticals, cosmetics, and food. Potential life-threatening hypersensitivity reactions to hidden molecules like macrogol may be under- diagnosed. Cases of immediate-type PEG hypersensitivity were reported with increasing frequency. The awareness regarding the allergenic potential of […]