SARS-CoV-2 Spike Ectodomain Targets α7 Nicotinic Acetycholine Receptors
Brittany C. V. O’Brien et al. Virus entry into animal cells is initiated by attachment to target macromolecules located on host cells. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) trimeric spike glycoprotein targets host angiotensin converting enzyme 2 to gain cellular access. The SARS-CoV-2 glycoprotein contains a neurotoxin-like region that has sequence similarities to […]
Amyloid and Hydrogel Formation of a Peptide Sequence from a Coronavirus Spike Protein
Valeria Casteletto, Ian W. Hamley Amyloid and Hydrogel Formation of a Peptide Sequence from a Coronavirus Spike Protein We demonstrate that a conserved coronavirus spike protein peptide forms amyloid structures, differing from the native helical conformation and not predicted by amyloid aggregation algorithms. We investigate the conformation and aggregation of peptide RSAIEDLLFDKV, which is a […]
