High-Dose Inhaled Nitric Oxide for the Treatment of Spontaneously Breathing Pregnant Patients With Severe Coronavirus Disease 2019 (COVID-19) Pneumonia

Carlo Valsecchi et al. Pneumonia related to coronavirus disease 2019 (COVID-19) is particularly threatening during pregnancy, because it may quickly progress to hypoxic respiratory failure requiring hospitalization and cardiopulmonary support … Moreover, the risk of obstetric complications, including preeclampsia, preterm delivery, and stillbirth, is also increased with COVID-19. To date, no respiratory therapies to complement […]

Distinct Immunological Signatures Discriminate Severe Covid-19 from Non-SARS-CoV-2-driven Critical Pneumonia

Stefanie Kreutmair, Susanne Unger, Nicolás Gonzalo Núñez, Michael Bitzer, Antoine Roquilly, Burkhard Becher  Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia Immune profiling of COVID-19 patients has identified numerous alterations in both innate and adaptive immunity. However, whether those changes are specific to SARS-CoV-2 or driven by a general inflammatory response shared across […]