Who Owns Who?
Ah Kahn Syed Two completely unrelated stories crossed my path this week and I am going to join them for you. … The big red line is there to show that these are totally separate stories, agreed? On the left you have the sudden rush from Moderna to sue Pfizer for patent infringement over the mRNA technology […]
SARS-CoV-2 and Influenza: A Comparative Overview and Treatment Implications
Laura D. Manzanares-Meza and Oscar Medina-Contreras Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Alphainfluenzavirus are RNA viruses that cause coronavirus disease-19 and influenza, respectively. Both viruses infect the respiratory tract, show similar symptoms, and use surface proteins to infect the host. Influenza requires hemagglutinin and neuraminidase to infect, whereas SARS-CoV-2 uses protein S. Both […]
COVID-19 RNA Based Vaccines and the Risk of Prion Disease
J. Bart Classen In this paper the Pfizer COVID-19 vaccine was evaluated for the potential to induce prion-based disease in vaccine recipients. The RNA sequence of the vaccine as well as the spike protein target interaction were analyzed for the potential to convert intracellular RNA binding proteins TAR DNA binding protein (TDP-43) and Fused in […]
Gut Microbiome May Help or Hinder Defenses Against SARS-CoV-2
Bianca Nogrady When SARS-CoV-2 first began rampaging around the world, it was thought to primarily affect the respiratory system. It soon became clear that the virus had more far-reaching effects, including on the gastrointestinal system and its bacterial symbionts. One early study suggested that nearly 20 percent of patients with confirmed SARS-CoV-2 infection had gastrointestinal symptoms. That […]
“Settling The Virus Debate” Statement
Tom Cowan et al. It has been more than two years since the onset of the “corona” crisis, which changed the trajectory of our world. The fundamental tenet of this crisis is that a deadly and novel “virus”, SARS-CoV-2, has spread around the world and negatively impacted large segments of humanity. Central to this tenet […]
When You Hear BNT162c(2), Run, Don’t Walk, RUN away.
Jessica Rose So as we all know by now, the messenger RNA in the COVID-19 Pfizer/BioNTech and Moderna products, is the mode of delivery of information for the cells in our bodies to make lots and lots of modified spike proteins. The ‘conventional’ modified mRNA is non-replicative because it does not include an RdRP (RdRPs […]
Investigator’s Brochure: BNT162/PF-07302048
BioNTech RNA Pharmaceuticals GmbH The development of a ribonucleic acid (RNA)-based vaccine encoding a viral antigen that is translated by the vaccinated organism to protein to induce a protective immune response provides significant advantages over more conventional vaccine approaches. At BioNTech, there are three different RNA platforms under development, namely non- modified uridine containing mRNA […]
Effects of N1-Methyl-Pseudouridine in the Pfizer mRNA Vaccine
Daniel B. Demers The use of messenger RNA (mRNA) vaccines has been developing since 1990. Historically, there have been three significant problems associated with mRNA vaccines. First, it has always been a challenge for vaccine developers to get the desired mRNA into the cells of choice (the delivery problem). Second, introducing a foreign RNA (the vaccine mRNA) […]
