Copper and its master protein, ceruloplasmin, are instrumental for mitochondrial function. Ceruloplasmin is what drives copper into the mitochondria, and each mitochondrion needs about 50,000 atoms of copper to do its work.
In a study it appears, when rats were denied copper, six genes (and subsequent proteins) are down-regulated or turned off, while one gene in particular, transferrin, is upregulated.
If you’re copper deficient, six genes will not function properly, and beyond these, there are at least 300 other genes that are also copper-dependent.
Your mitochondria also require copper for optimal function, and mitochondrial dysfunction is a driver of virtually all chronic disease and ill health.