el gato malo
i’ve spoken quite a lot about why leaky vaccines drive viral evolution to select for vaccine advantage. rolling out non-sterilizing vaccines is is terrible idea. it’s like only taking half your course of antibiotics and then wondering why MRSA is suddenly everywhere. it’s just a selector for resistance and advantage. the basic mechanism is really very simple: antigens that were recessive become dominant in order to evade the fixated immune response generated by an inoculant that did not work to stop colonization, carriage, and contagion.
this is the simple, predictable, and inevitable outcome of herd level antigenic fixation whereby most people are all locked into the same increasingly ineffective immune response and fail to generate new responses when faced with novel pathogens. this gets called OAS/hoskins effect.