The concept of the human body as a microcosm of the Universe is one of the most fundamental concepts of Ayurveda. This concept is known as loka-purusha sāmya siddhanta (loka-universe; purusha-human being; samya-sameness; siddhanta-teaching). Ayurveda views the entire creation, including the human body, to be constituted from five fundamental elements (pañca mahabhutas). The uniquely balanced configuration of these five elements in each unique individual creates normalcy or health and deviations from this normalcy in any direction causes disease. Thus the knowledge and restoration of normalcy of these five fundamental elements is the cornerstone of treatment in Ayurveda.