Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2

Takashi Tanikawa et al.

The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged as a pandemic and has inflicted enormous damage on the lives of the people and economy of many countries worldwide. However, therapeutic agents against SARS-CoV-2 remain unclear. SARS-CoV-2 has a spike protein (S protein), and cleavage of the S protein is essential for viral entry. Nattokinase is produced by Bacillus subtilis var. natto and is beneficial to human health. In this study, we examined the effect of nattokinase on the S protein of SARS-CoV-2. When cell lysates transfected with S protein were incubated with nattokinase, the S protein was degraded in a dose- and time-dependent manner. Immunofluorescence analysis showed that S protein on the cell surface was degraded when nattokinase was added to the culture medium. Thus, our findings suggest that nattokinase exhibits potential for the inhibition of SARS-CoV-2 infection via S protein degradation.

Latest articles

Byram W. Bridle … In response to a great question about a...
Vesanto Melina Soy has been the focus of considerable controversy. The roots...
Mark Messina … Isoflavones are classified as both phytoestrogens and selective estrogen...
BRMI … The lymphatic system lacks an organ that acts as a...
Jiacheng Huang et al. The extracellular matrix (ECM) is one of the...

Thank you!

Thank you for your membership application. As soon as your payment has been received your membership will be activated and you will be informed via email.

Thank you.

Thank you!

The form has been submitted successfully!