Effects of Previous Infection and Vaccination on Symptomatic Omicron Infections

Heba N. Altarawneh et al.

No notable differences were observed in the effectiveness against BA.1 and BA.2 of previous
infection, vaccination, and hybrid immunity. Protection from previous infection with variants other than omicron against reinfection was moderate and durable, but protection of primary-series vaccination against infection was negligible by 6 months after the second dose. Recent booster vaccination had moderate effectiveness, whereas hybrid immunity from previous infection and recent booster vaccination conferred the strongest protection against infection, at approximately 80%. All five forms of immunity were associated with strong and durable protection against Covid-19–related hospitalization and death.

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