… three different microbial species have developed resistance to glyphosate by swapping out a glycine residue at the site where the substrate phosphoenol pyruvate (PEP) is secured in place. All three microbes have replaced this glycine residue with alanine (adding one extra methyl group). This results in a reduction in the efficiency of the protein, but, most remarkably, completely protects it from any suppression by glyphosate.
… I strongly suspect that substitution of glyphosate for glycine in myosin and other molecular motors is a causative factor in chronic fatigue syndrome and ALS.
… Two things to consider when thinking of proteins that might be most affected by this substitution error are the expression rate of the protein and the percentage of the protein that constitutes glycine residues. When you take these factors into consideration, one molecule stands out: collagen. Collagen is the most abundant protein in the body—one in every four protein molecules in our body is collagen. Collagen is what gives our joints, bones and skin strength and elasticity.