Histamine excess is part of inflammatory reactions caused by many factors of modern life (NF-kB is part of the inflammatory pathways) and when the inflammation keeps escalating it may increase risk for misfolded protein accumulation leading to cell death. This occurs in the hippocampus in Alzheimer’s patients as NMDA receptor over activity is also involved and both NMDA and H1 histamine receptors are more concentrated within the hippocampus.
… This article contains a potential mechanism of action for how histamine excess and NMDA receptor overactivity may combine in damaging the hippocampus in Alzheimer’s dementia and other neurocognitive conditions. It also includes lifestyle and diet strategies that might help stop the escalating hyperinflammation of overactive mast cells, too much NF-kB and not enough Nrf2.
… Lifestyle factors are important for reducing the promotion of inflammatory NF-kB and instead promoting anti-inflammatory Nrf2 – water, sunshine, exercise, sleep with black-out curtain level dark or eye cover and avoid EMF. Fibrinolytics to help break down fibrotic build-up before it is excessive may be helpful in inflammatory conditions and may be critical in CoV care.