Ivermectin is an anti-parasitic agent that has gained attention as a potential COVID-19 therapeutic. It is a compound of the type Avermectin, which is a fermented by-product of Streptomyces avermitilis. Bifidobacterium is a member of the same phylum as Streptomyces spp., suggesting it may have a symbiotic relation with Streptomyces. Decreased Bifidobacterium levels are observed in COVID-19 susceptibility states, including old age, autoimmune disorder, and obesity.
… We are hypothesizing the IVM mechanism of action as a therapeutic for COVID-19 is through feeding of Bifidobacterium, which then inhibits cytokine function and tames the cytokine storm. As such, IVM should be administered at the time of the cytokine storm.