microRNA Are the Real Regulators of Gene Transcription

Jennifer Depew

MicroRNA are non-coding short lengths of nucleotides (19-23 nucleotides) that have regulatory control over whether an mRNA will be transcribed into a protein or degraded by the cell. MicroRNAs affect specific mRNA and their proteins but may be able to affect 100s of them so it is not a simple thing to study or to say miRNA type A does this one specific thing consistently every time. Chronic illnesses have been found to show patterns in which miRNA are present in different amounts than in normal health, whether up or down regulated – not typical.

Good news – plant polyphenols seem to provide very beneficial and multiple effects on microRNA and the downstream mRNA, protein transcription, and chemical pathway activation or inhibition.

Nine polyphenols were tested and found to effect similar miRNA and similar pathways – reducing oxidative stress and inflammation and improving blood lipid chemistry in the apo e -/- knockout mouse used in the study in comparison to normal/wildtype mice.

Latest articles

William J. Walsh Each of us has innate biochemical factors which influence...
Joanna Moncrieff et al. The serotonin hypothesis of depression is still influential....
Raymond J. Pataracchia Biochemical syndromes of importance in mood and behaviour disorders...
Orthomolecular Medicine News Service Doctors report that mental health problems including depression,...
David R. Hawkins et al. Over the years a great many biochemical...
A Midwestern Doctor Many people believe the most significant issues facing the...

Thank you!

Thank you for your membership application. As soon as your payment has been received your membership will be activated and you will be informed via email.

Thank you.

Thank you!

The form has been submitted successfully!