Pfizer documents: Pharmacokinetics Written Summary

Released March 1, 2022

The ADME profile of BNT162b2 (BioNTech code number BNT162, Pfizer code number PF-07302048) included evaluation of the PK and metabolism of two novel lipid excipients (ALC-0315 and ALC-0159) in the LNP and potential biodistribution using luciferase expression as a surrogate reporter or a radiolabeled lipid marker … Over 48 hours, the radiolabel distributed mainly to the liver, adrenal glands, spleen and ovaries, with maximum concentrations observed at 8-48 hours post-dose.

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