The three regions of the brain being targeted are the temporal cortex, cerebellum, and prefrontal
cortex, especially the frontal lobe. These regions were shown to have lower methylation levels of
the X chromosome with ASD. The study specifies that X chromosome deletion occurs by “epigenetic dysregulation” (gene deletion) and “DNA methylation” (genetic coding).
… Targeted deletion of the X chromosome in other areas of the brain result in ASD conditions such as Angelman syndrome and Prader-Willi syndrome. Deletion of the X chromosome in females causes Turner syndrome which induces mental retardation, developmental delay and effects social reciprocity and communication, a condition of ASD.