The Importance of Oxidant Injury as a Cause of Impaired Mitochondrial Oxidation in Diabetes

Joh. P. Cleary

If diabetes results from low cell ATP [adenosine triphosphate], then attempts to restore the energy production system should improve or cure diabetes. Complete recovery depends on the number of viable beta cells left in the pancreas that can be restored to insulin production, however the complications of diabetes may be ameliorated by restoring normal energy production to the rest of the body even though insulin must be given in addition.

Biochemical abnormalities of diabetes include excessive ketone body formation with ketonuria and acidosis or excessive H+ ion accumulation. When normal metabolic pathways of the citric acid cycle are disrupted, the oxidation of hydrogen ion and the combining with oxygen in the cytochrome system of the mitochondria is defective. Niacin corrects this.

… Since diabetes is the leading cause of blindness, treatment with nicotinic acid and the omega 3 fatty acids may reverse the abnormal metabolism and prevent blindness in diabetes.

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