Carlo Valsecchi et al.

Pneumonia related to coronavirus disease 2019 (COVID-19) is particularly threatening during pregnancy, because it may quickly progress to hypoxic respiratory failure requiring hospitalization and cardiopulmonary support … Moreover, the risk of obstetric complications, including preeclampsia, preterm delivery, and stillbirth, is also increased with COVID-19.

To date, no respiratory therapies to complement supplemental oxygenation have been tested in randomized clinical trials targeting pregnant patients with COVID-19.

… This is a retrospective cohort study that was designed to assess the safety efficacy of iNO₂₀₀ in the treatment of pregnant patients hospitalized for severe bilateral COVID-19 pneumonia. 

… We assessed the safety and efficacy of the addition of twice-daily treatment with iNO₂₀₀ to standard of care alone and found that iNO₂₀₀ was associated with improved oxygenation and decreased dyspnea. When compared with standard of care alone, iNO₂₀₀ was associated with a reduction of the duration of oxygen supplementation and hospital and ICU length of stay. This innovative respiratory intervention was feasible in pregnant patients with COVID-19 pneumonia, and no adverse events occurred in mothers or infants.