High-Dose Inhaled Nitric Oxide for the Treatment of Spontaneously Breathing Pregnant Patients With Severe Coronavirus Disease 2019 (COVID-19) Pneumonia

Carlo Valsecchi et al.

Pneumonia related to coronavirus disease 2019 (COVID-19) is particularly threatening during pregnancy, because it may quickly progress to hypoxic respiratory failure requiring hospitalization and cardiopulmonary support … Moreover, the risk of obstetric complications, including preeclampsia, preterm delivery, and stillbirth, is also increased with COVID-19.

To date, no respiratory therapies to complement supplemental oxygenation have been tested in randomized clinical trials targeting pregnant patients with COVID-19.

… This is a retrospective cohort study that was designed to assess the safety efficacy of iNO200 in the treatment of pregnant patients hospitalized for severe bilateral COVID-19 pneumonia. 

… We assessed the safety and efficacy of the addition of twice-daily treatment with iNO200 to standard of care alone and found that iNO200 was associated with improved oxygenation and decreased dyspnea. When compared with standard of care alone, iNO200 was associated with a reduction of the duration of oxygen supplementation and hospital and ICU length of stay. This innovative respiratory intervention was feasible in pregnant patients with COVID-19 pneumonia, and no adverse events occurred in mothers or infants.

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